The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Nov. 17, 2010
Wei Gong, Woburn, MA (US);
Sudhanshu Dole, North Andover, MA (US);
Tammy Grabar, Reading, MA (US);
Andrew Christopher Collard, Sommerville, MA (US);
Janice G. Pero, Lexington, MA (US);
R. Rogers Yocum, Lexington, MA (US);
Wei Gong, Woburn, MA (US);
Sudhanshu Dole, North Andover, MA (US);
Tammy Grabar, Reading, MA (US);
Andrew Christopher Collard, Sommerville, MA (US);
Janice G. Pero, Lexington, MA (US);
R. Rogers Yocum, Lexington, MA (US);
Myriant Corporation, Quincy, MA (US);
Abstract
This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.