The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Dec. 05, 2012
Ohio State Innovation Foundation, Columbus, OH (US);
Ahmed E. Yousef, Columbus, OH (US);
Yaoqi Guo, Columbus, OH (US);
En Huang, Columbus, OH (US);
Chunhua Yuan, Columbus, OH (US);
Liwen Zhang, Delaware, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Abstract
Provided herein is a biologically pure culture of, identified as OSY-SE, as well as an antimicrobial agent isolated and/or purified from the culture having any one of SEQ ID NOs:1-3 and 64-66. The disclosure also provides compositions and articles of manufacture comprising an antimicrobial agent and/or the bacterial cell of, identified as OSY-SE. Further provided are methods of use, including methods of affecting microbial activity, methods of inhibiting growth and/or proliferation of a microbe, methods of treating a condition or disease associated with the presence of a microbe, and methods of treating a microbial infection in a subject comprising contacting a microbial cell with at least one active agent of SEQ ID NOs:1-3 and 64-66 and/or the bacterial cell, identified as OSY-SE. The disclosure also provides the biosynthetic machinery (e.g., utilizing a NRPS mechanism) including isolated proteins, isolated polynucleotides, vectors, and host cells for production of the antimicrobials described herein.