The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Jul. 10, 2012
Jun-ming Shih, Taoyuan County, TW;
Yuan-ruei Huang, Taoyuan County, TW;
Yu-lung Wu, Taoyuan County, TW;
Shih-ying Lee, Taoyuan County, TW;
Kang-wei Chang, Taoyuan County, TW;
Chia-chien Chen, Taoyuan County, TW;
Jun-Ming Shih, Taoyuan County, TW;
Yuan-Ruei Huang, Taoyuan County, TW;
Yu-Lung Wu, Taoyuan County, TW;
Shih-Ying Lee, Taoyuan County, TW;
Kang-Wei Chang, Taoyuan County, TW;
Chia-Chien Chen, Taoyuan County, TW;
Institute of Nuclear Energy Research, Atomic Energy Council, Lungtan, Taoyuan, TW;
Abstract
A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.