The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2015
Filed:
Dec. 25, 2009
Applicants:
Masaaki Suzuki, Koube, JP;
Hisashi Doi, Koube, JP;
Hiroko Koyama, Gifu, JP;
Inventors:
Assignee:
Riken, Wako-Shi, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 221/00 (2006.01); C07D 217/02 (2006.01); C07D 333/08 (2006.01); C07D 307/36 (2006.01); C07D 231/12 (2006.01); C07D 237/08 (2006.01); C07D 239/26 (2006.01); C07D 213/127 (2006.01);
U.S. Cl.
CPC ...
C07D 213/127 (2013.01); C07D 217/02 (2013.01); C07D 231/12 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 307/36 (2013.01); C07D 333/08 (2013.01);
Abstract
Provided is a method whereby a heteroaromatic ring aryl can be very rapidly methylated at a high yield. In an N-alkyl-2-pyrrolidinone, a heteroaromatic ring aryltrialkylstannan is cross-coupled with methyl iodide in the presence of a palladium complex, a phosphine ligand, a cuprous halide, a carbonic acid salt and/or an alkali metal fluoride to thereby rapidly methylate the heteroaromatic ring aryl. (Formula shows a case wherein the heteroaromatic ring aryl is a pyridyl group.)