The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2015
Filed:
Jan. 13, 2012
Nancy Sullivan, Kensington, MD (US);
Bimal Chakrabarti, Gaithersberg, MD (US);
Zhi-yong Yang, Potomac, MD (US);
Maria Grazia Pau, Leiden, NL;
Jaap Goudsmit, Amsterdam, NL;
Gary Nabel, Washington, DC (US);
Nancy Sullivan, Kensington, MD (US);
Bimal Chakrabarti, Gaithersberg, MD (US);
Zhi-Yong Yang, Potomac, MD (US);
Maria Grazia Pau, Leiden, NL;
Jaap Goudsmit, Amsterdam, NL;
Gary Nabel, Washington, DC (US);
Abstract
The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.