The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2015

Filed:

Dec. 28, 2012
Applicants:

Global Blood Therapeutics, Inc., Boston, MA (US);

Cytokinetics, Inc., South San Francisco, CA (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Brian Metcalf, Moraga, CA (US);

Chihyuan Chuang, Millbrae, CA (US);

Jeffrey Warrington, San Mateo, CA (US);

Kumar Paulvannan, San Jose, CA (US);

Matthew P. Jacobson, San Francisco, CA (US);

Lan Hua, Mountain View, CA (US);

Bradley Morgan, Moraga, CA (US);

Assignees:

Global Blood Therapeutics, Inc., South San Francisco, CA (US);

Cytokinetics, Inc., South San Francisco, CA (US);

The Regents of the University of California, Oakland, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 471/04 (2006.01); C07D 213/80 (2006.01); C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 213/69 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 213/80 (2013.01); C07D 471/04 (2013.01); C07D 401/14 (2013.01); C07D 401/12 (2013.01); C07D 213/69 (2013.01);
Abstract

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.


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