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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9012443 B1

PDFFull Text
Date of Patent:
Apr. 21, 2015

Filed:

Dec. 06, 2012

Bicyclic aryl and heteroaryl sodium channel inhibitors

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Christiane Boezio, Somerville, MA (US);

Howard Bregman, Melrose, MA (US);

James R. Coats, Oak Harbor, WA (US);

Erin F. Dimauro, Cambridge, MA (US);

Thomas Dineen, Somerville, WA (US);

Bingfan Du, Cambridge, MA (US);

Russell Graceffa, Hampton, NH (US);

Charles Kreiman, Belmont, MA (US);

Daniel La, Brookline, MA (US);

Isaac E. Marx, Cambridge, MA (US);

Nagasree Chakka, Lexington, MA (US);

Hanh Nho Nguyen, Arlington, MA (US);

Emily Anne Peterson, Cambridge, MA (US);

Matthew Weiss, Boston, MA (US);

Katrina W. Copeland, Sudbury, MA (US);

Holly L. Deak, Brookline, MA (US);

Alessandro Boezio, Somerville, MA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:

Elsa D. Lemoine

Primary Examiner:

Yong Chu

Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61K 31/433 (2006.01); C07D 403/12 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 239/42 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 277/52 (2006.01); C07D 285/08 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); C07D 401/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 403/12 (2013.01); C07D 413/14 (2013.01); C07D 401/12 (2013.01); C07D 403/14 (2013.01); C07D 239/42 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 277/52 (2013.01); C07D 285/08 (2013.01);
Abstract

The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

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