The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2015

Filed:

Apr. 17, 2007
Applicants:

Marc Antonius Theodorus Bisschops, Breda, NL;

Jozef Anton Mari Pennings, Den Haag, NL;

Jacob Arthur Tijsterman, Haarlem, NL;

Inventors:
Assignee:

Xendo Holding B.V., Leiden, NL;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 1/18 (2006.01); B01D 15/18 (2006.01); C07K 1/22 (2006.01); C07K 1/36 (2006.01); G01N 30/46 (2006.01); G01N 30/52 (2006.01);
U.S. Cl.
CPC ...
C07K 1/18 (2013.01); B01D 15/1807 (2013.01); B01D 15/1821 (2013.01); B01D 15/1864 (2013.01); C07K 1/22 (2013.01); C07K 1/36 (2013.01); G01N 30/468 (2013.01); G01N 2030/527 (2013.01);
Abstract

A method and system is provided for yielding biopharmaceutical products involving a chromatographic separation process. The method comprises: providing a plurality of membrane adsorber cartridges; providing a plurality of valves, communicatively coupled to said plurality of membrane adsorber cartridges; and switching the valves, so as to interconnect said membrane adsorber cartridges to operate in a countercurrent flow mode. The system comprises multiple membrane adsorber cartridges that are interconnected and configured to operate in a countercurrent flow mode. Furthermore, the configuration comprises a valve assembly that allows the cartridges to be subjected to different steps in the process by automatic switching of the valves. In this way, cartridges are recycled many times during the purification of a batch.


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