The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2015
Filed:
Sep. 14, 2012
David B. Rozema, Middleton, WI (US);
David L. Lewis, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Torsten Hoffmann, Weil am Rhein, DE;
Eric Kitas, Baselland, CH;
Peter Mohr, Basel, CH;
Philipp Hadwiger, Kulmbach, DE;
Wilma Thuer, Kulmbach, DE;
Linda Valis, Bamberg, DE;
David B. Rozema, Middleton, WI (US);
David L. Lewis, Madison, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Torsten Hoffmann, Weil am Rhein, DE;
Eric Kitas, Baselland, CH;
Peter Mohr, Basel, CH;
Philipp Hadwiger, Kulmbach, DE;
Wilma Thuer, Kulmbach, DE;
Linda Valis, Bamberg, DE;
Arrowhead Madison Inc., Madison, WI (US);
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.