The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2015

Filed:

Nov. 03, 2009
Applicants:

Mary K. Yagodich, Bryn Mawr, PA (US);

Michael P. Citron, Chester Springs, PA (US);

Daniel J. Distefano, Harleysville, PA (US);

Daniel L. Krah, Lansdale, PA (US);

Xiaoping Liang, Collegeville, PA (US);

Inventors:

Mary K. Yagodich, Bryn Mawr, PA (US);

Michael P. Citron, Chester Springs, PA (US);

Daniel J. Distefano, Harleysville, PA (US);

Daniel L. Krah, Lansdale, PA (US);

Xiaoping Liang, Collegeville, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/155 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/45 (2006.01); C12N 15/63 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/155 (2013.01); A61K 2039/5254 (2013.01); C12N 7/00 (2013.01); C12N 2760/18522 (2013.01); C12N 2760/18534 (2013.01); C12N 2760/18564 (2013.01);
Abstract

The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when administered to a subject but substantially retain the antigenic and immunogenic properties of wild-type RSV.


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