The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2015
Filed:
Sep. 09, 2013
Applicants:
Boreal Genomics, Inc., Mountain View, CA (US);
The University of British Columbia, Vancouver, CA;
Inventors:
Andrea Marziali, North Vancouver, CA;
Nitin Sood, Los Altos, CA (US);
Assignees:
Boreal Genomics, Inc., Mountain View, CA (US);
The University of British Columbia, Vancouver, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/447 (2006.01); B03C 1/30 (2006.01); B03C 5/02 (2006.01); C12N 15/10 (2006.01); C12Q 1/68 (2006.01); G01N 1/40 (2006.01);
U.S. Cl.
CPC ...
G01N 27/447 (2013.01); G01N 27/44713 (2013.01); G01N 2001/4038 (2013.01); B03C 1/30 (2013.01); B03C 5/026 (2013.01); C12N 15/101 (2013.01); C12Q 1/68 (2013.01);
Abstract
Methods and apparatus providing improved fidelity and specificity when separating nucleic acids from a sample, but without need for amplification. In particular, using the disclosed methods, it is possible to isolate a variant nucleic acid (i.e., a mutation) from a non-target nucleic acid (i.e., a wild-type) when the variant is present in the original sample at a much lower concentration than the non-target, e.g., 1:10,000, without substantial loss of the variant.