The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2015

Filed:

Feb. 02, 2011
Applicants:

Marcia J. Kieliszewski, Albany, OH (US);

Jianfeng Xu, Athens, OH (US);

Gary D. Meyer, Athens, OH (US);

Inventors:

Marcia J. Kieliszewski, Albany, OH (US);

Jianfeng Xu, Athens, OH (US);

Gary D. Meyer, Athens, OH (US);

Assignee:

Ohio University, Athens, OH (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); C12N 15/18 (2006.01); C12N 15/20 (2006.01); C12N 15/62 (2006.01); C07H 21/04 (2006.01); C07K 14/415 (2006.01); C07K 14/61 (2006.01); C07K 14/765 (2006.01); C12P 21/00 (2006.01); C07K 14/56 (2006.01); A61K 38/21 (2006.01); A61K 38/27 (2006.01);
U.S. Cl.
CPC ...
C07K 14/415 (2013.01); A61K 38/27 (2013.01); C07K 14/61 (2013.01); C07K 14/765 (2013.01); C12N 15/62 (2013.01); C12N 15/8257 (2013.01); C12P 21/005 (2013.01); C07K 14/56 (2013.01);
Abstract

Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion are present. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are also present.


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