The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Apr. 27, 2012
James M. Cook, Milwaukee, WI (US);
Terry S. Clayton, Colorado Springs, CO (US);
Hiteshkumar D. Jain, Mumbai, IN;
Sundari K. Rallipalli, Oak Creek, WI (US);
Yun Teng Johnson, Glendale, WI (US);
Jie Yang, Renssalaer, NY (US);
Michael Ming-jin Poe, Milwaukee, WI (US);
Ojas A. Namjoshi, Cary, NC (US);
Zhi-jian Wang, Whitefish Bay, WI (US);
James M. Cook, Milwaukee, WI (US);
Terry S. Clayton, Colorado Springs, CO (US);
Hiteshkumar D. Jain, Mumbai, IN;
Sundari K. Rallipalli, Oak Creek, WI (US);
Yun Teng Johnson, Glendale, WI (US);
Jie Yang, Renssalaer, NY (US);
Michael Ming-jin Poe, Milwaukee, WI (US);
Ojas A. Namjoshi, Cary, NC (US);
Zhi-jian Wang, Whitefish Bay, WI (US);
UWM Research Foundation, Inc., Milwaukee, WI (US);
Abstract
Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.