The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2015

Filed:

Aug. 11, 2010
Applicants:

Kazuki Nakayama, Tokyo, JP;

Daiki Sakai, Kanagawa, JP;

Kazutoshi Watanabe, Tokyo, JP;

Toshiyuki Kohara, Kanagawa, JP;

Keiichi Aritomo, Tokyo, JP;

Inventors:

Kazuki Nakayama, Tokyo, JP;

Daiki Sakai, Kanagawa, JP;

Kazutoshi Watanabe, Tokyo, JP;

Toshiyuki Kohara, Kanagawa, JP;

Keiichi Aritomo, Tokyo, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/536 (2006.01); A61K 31/505 (2006.01); A61K 31/55 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 265/14 (2006.01); C07D 401/12 (2006.01); C07D 233/76 (2006.01); C07D 401/14 (2006.01); C07D 407/12 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 233/76 (2013.01); C07D 401/14 (2013.01); C07D 407/12 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01);
Abstract

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; Ris hydrogen atom or a C-Calkyl group; L represents single bond or a C-Calkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; Rrepresents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).


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