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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9006190 B1

PDFFull Text
Date of Patent:
Apr. 14, 2015

Filed:

Jan. 06, 2009

Compositions and methods for cancer diagnosis and therapy

Applicants:

Carlo Croce, Philadelphia, PA (US);

George Calin, Philadelphia, PA (US);

Inventors:

Carlo Croce, Philadelphia, PA (US);

George Calin, Philadelphia, PA (US);

Assignee:

Thomas Jefferson University, Philadelphia, PA (US);

Attorney:

Hamilton, Brook, Smith & Reynolds, P.C.

Primary Examiner:

Quang Nguyen

Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61K 9/127 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 31/70 (2013.01); A61K 48/005 (2013.01); C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); C12N 2310/141 (2013.01); C12N 2330/10 (2013.01); C12Q 2600/178 (2013.01);
Abstract

The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases.

Find Patent Forward Citations

Croce, Carlo. (2015). Compositions and methods for cancer diagnosis and therapy (U.S. Patent No. 9006190). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9006190

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