The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Jan. 12, 2010
Thomas Mitts, Visalia, CA (US);
Felipe Jimenez, Seal Beach, CA (US);
Aleksander Hinek, Toronto, CA;
Severa Bunda, Toronto, CA;
Thomas Mitts, Visalia, CA (US);
Felipe Jimenez, Seal Beach, CA (US);
Aleksander Hinek, Toronto, CA;
Severa Bunda, Toronto, CA;
Human Matrix Sciences, LLC, Visalia, CA (US);
The Hospital for Sick Children, Toronto, ON, CA;
Abstract
The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.