The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Oct. 14, 2009
Christophe Blanchetot, Destelbergen, BE;
Martine Smit, Amsterdam, NL;
Regorius Leurs, Amsterdam, NL;
Sven Jähnichen, Amsterdam, NL;
Dominique Schols, Herentals, BE;
Michael John Scott Saunders, Brussels, BE;
Johannes Joseph Wilhelmus DE Haard, Oudelande, NL;
Peter Vanlandschoot, Bellem, BE;
Peter Verheesen, Ghent, BE;
Christophe Blanchetot, Destelbergen, BE;
Martine Smit, Amsterdam, NL;
Regorius Leurs, Amsterdam, NL;
Sven Jähnichen, Amsterdam, NL;
Dominique Schols, Herentals, BE;
Michael John Scott Saunders, Brussels, BE;
Johannes Joseph Wilhelmus De Haard, Oudelande, NL;
Peter Vanlandschoot, Bellem, BE;
Peter Verheesen, Ghent, BE;
Ablynx N.V., Zwijnaarde, BE;
Abstract
The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. NANOBODIES specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.