The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Jul. 27, 2006
Ian Maclachlan, Mission, CA;
Lloyd B. Jeffs, Delta, CA;
Edward Yaworski, Maple Ridge, CA;
Kieu Lam, Surrey, CA;
Ian MacLachlan, Mission, CA;
Lloyd B. Jeffs, Delta, CA;
Edward Yaworski, Maple Ridge, CA;
Kieu Lam, Surrey, CA;
Protiva Biotherapeutics, Inc., Burnaby, BC, CA;
Abstract
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.