The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2015

Filed:

Nov. 16, 2012
Applicants:

The Johns Hopkins University, Baltimore, MD (US);

St. Jude Children's Research Hospital Inc., Memphis, TN (US);

Inventors:

Drew M Pardoll, Brookeville, MD (US);

Ching-Tai Huang, Taipei, TW;

Jonathan Powell, Baltimore, MD (US);

Charles Drake, Baltimore, MD (US);

Dario A Vignali, Germantown, TN (US);

Creg J Workman, Memphis, TN (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/38 (2006.01); A61K 39/395 (2006.01); A01K 67/027 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C07K 16/42 (2006.01); A61K 35/12 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A01K 67/0271 (2013.01); A01K 67/0276 (2013.01); A61K 39/0011 (2013.01); C07K 14/70503 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); A61K 39/3955 (2013.01); C07K 16/42 (2013.01); A01K 2267/0381 (2013.01); A61K 2035/122 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/55516 (2013.01); C12N 2501/599 (2013.01); C12N 2510/00 (2013.01); C12N 2799/027 (2013.01);
Abstract

Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be a monoclonal antibody. The amount of the antibody administered may be sufficient to enhance an immune T cell response to the cancer.


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