The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Dec. 07, 2010
Holbrook Kohrt, Santa Clara, CA (US);
Roch Houot, Rennes, FR;
Ronald Levy, Stanford, CA (US);
Arash Ash Alizadeh, San Mateo, CA (US);
Matthew J. Goldstein, Hillsborough, CA (US);
James Torchia, Stanford, CA (US);
Holbrook Kohrt, Santa Clara, CA (US);
Roch Houot, Rennes, FR;
Ronald Levy, Stanford, CA (US);
Arash Ash Alizadeh, San Mateo, CA (US);
Matthew J. Goldstein, Hillsborough, CA (US);
James Torchia, Stanford, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.