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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8999999 B1

PDFFull Text
Date of Patent:
Apr. 07, 2015

Filed:

Jan. 22, 2013

Use of inhibitors of bruton's tyrosine kinase (btk)

Applicant:

Pharmacyclics, Inc., Sunnyvale, CA (US);

Inventors:

Joseph J. Buggy, Mountain View, CA (US);

Laurence Elias, Berkeley, CA (US);

Gwen Fyfe, San Francisco, CA (US);

Eric Hedrick, Summit, NJ (US);

David J. Loury, San Jose, CA (US);

Tarak D. Mody, Sunnyvale, CA (US);

Assignee:

Pharmacyclics, Inc., Sunnyvale, CA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Uma Ramachandran

Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61P 35/02 (2006.01); C07D 487/04 (2006.01); A61K 31/337 (2006.01); A61K 31/195 (2006.01); A61K 31/436 (2006.01); A61K 31/454 (2006.01); A61K 31/475 (2006.01); A61K 31/573 (2006.01); A61K 31/606 (2006.01); A61K 31/675 (2006.01); A61K 31/69 (2006.01); A61K 31/704 (2006.01); A61K 31/7076 (2006.01); A61K 45/06 (2006.01); A61K 31/4184 (2006.01); A61K 31/4745 (2006.01); A61K 31/7032 (2006.01); A61K 39/395 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
A61K 31/337 (2013.01); A61K 31/195 (2013.01); A61K 31/436 (2013.01); A61K 31/454 (2013.01); A61K 31/475 (2013.01); A61K 31/519 (2013.01); A61K 31/573 (2013.01); A61K 31/606 (2013.01); A61K 31/675 (2013.01); A61K 31/69 (2013.01); A61K 31/704 (2013.01); A61K 31/7076 (2013.01); A61K 45/06 (2013.01); A61K 31/4184 (2013.01); A61K 31/4745 (2013.01); A61K 31/7032 (2013.01); A61K 39/395 (2013.01); C07D 487/04 (2013.01); A61K 31/437 (2013.01); A61K 39/3955 (2013.01);
Abstract

Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

Find Patent Forward Citations

Buggy, Joseph. (2015). Use of inhibitors of bruton's tyrosine kinase (btk) (U.S. Patent No. 8999999). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8999999

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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