The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 2015

Filed:

Jul. 02, 2010
Applicants:

Paul Gibbons, San Francisco, CA (US);

Emily Hanan, Redwood City, CA (US);

Wendy Liu, Foster City, CA (US);

Joseph P. Lyssikatos, Piedmont, CA (US);

Steven R. Magnuson, Dublin, CA (US);

Rohan Mendonca, Pleasanton, CA (US);

Richard Pastor, San Francisco, CA (US);

Thomas E. Rawson, Mountain View, CA (US);

Michael Siu, Burlingame, CA (US);

Mark Zak, San Mateo, CA (US);

Aihe Zhou, San Jose, CA (US);

Bing-yan Zhu, Palo Alto, CA (US);

Inventors:

Paul Gibbons, San Francisco, CA (US);

Emily Hanan, Redwood City, CA (US);

Wendy Liu, Foster City, CA (US);

Joseph P. Lyssikatos, Piedmont, CA (US);

Steven R. Magnuson, Dublin, CA (US);

Rohan Mendonca, Pleasanton, CA (US);

Richard Pastor, San Francisco, CA (US);

Thomas E. Rawson, Mountain View, CA (US);

Michael Siu, Burlingame, CA (US);

Mark Zak, San Mateo, CA (US);

Aihe Zhou, San Jose, CA (US);

Bing-Yan Zhu, Palo Alto, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01);
Abstract

A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R, Rand Rare defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.


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