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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8999975 B1

PDFFull Text
Date of Patent:
Apr. 07, 2015

Filed:

Sep. 14, 2012

Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c

Applicants:

Marc Grundl, Biberach an der Riss, DE;

Thorsten Oost, Biberach an der Riss, DE;

Alexander Pautsch, Biberach an der Riss, DE;

Stefan Peters, Biberach an der Riss, DE;

Doris Riether, Biberach an der Riss, DE;

Wolfgang Wienen, Biberach an der Riss, DE;

Inventors:

Marc Grundl, Biberach an der Riss, DE;

Thorsten Oost, Biberach an der Riss, DE;

Alexander Pautsch, Biberach an der Riss, DE;

Stefan Peters, Biberach an der Riss, DE;

Doris Riether, Biberach an der Riss, DE;

Wolfgang Wienen, Biberach an der Riss, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

Mary-Ellen M. Devlin

Anthony P. Bottino

Primary Examiner:

Savitha Rao

Assistant Examiner:

Angela Brown-Pettigrew

Int. Cl.
CPC ...
C07D 209/52 (2006.01); A61K 31/416 (2006.01); A61K 31/4178 (2006.01); A61K 31/437 (2006.01); C07D 519/00 (2006.01); A61K 31/538 (2006.01); A61K 31/4709 (2006.01); C07D 495/04 (2006.01); A61K 31/4725 (2006.01); A61K 31/536 (2006.01); C07D 401/14 (2006.01); A61K 31/551 (2006.01); A61K 31/501 (2006.01); A61K 31/4439 (2006.01); A61K 31/4365 (2006.01); A61K 31/404 (2006.01); A61K 45/06 (2006.01); A61K 31/506 (2006.01); A61K 31/4184 (2006.01); A61K 31/454 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); A61K 31/4155 (2006.01); A61K 31/4192 (2006.01); C07D 413/12 (2006.01); A61K 31/4035 (2006.01); A61K 31/428 (2006.01); A61K 31/423 (2006.01); A61K 31/403 (2006.01); C07D 405/12 (2006.01); C07D 471/08 (2006.01); C07D 487/04 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); A61K 31/4985 (2006.01); A61K 31/4245 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
C07D 209/52 (2013.01); A61K 31/416 (2013.01); A61K 31/4178 (2013.01); A61K 31/437 (2013.01); C07D 519/00 (2013.01); A61K 31/538 (2013.01); A61K 31/4709 (2013.01); C07D 495/04 (2013.01); A61K 31/4725 (2013.01); A61K 31/536 (2013.01); C07D 401/14 (2013.01); A61K 31/551 (2013.01); A61K 31/501 (2013.01); A61K 31/4439 (2013.01); A61K 31/4365 (2013.01); A61K 31/404 (2013.01); A61K 45/06 (2013.01); A61K 31/506 (2013.01); A61K 31/4184 (2013.01); A61K 31/454 (2013.01); C07D 401/12 (2013.01); C07D 471/04 (2013.01); A61K 31/4155 (2013.01); A61K 31/4192 (2013.01); C07D 413/12 (2013.01); A61K 31/4035 (2013.01); A61K 31/428 (2013.01); A61K 31/423 (2013.01); A61K 31/403 (2013.01); C07D 405/12 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01); A61K 31/4985 (2013.01); A61K 31/4245 (2013.01); A61K 31/517 (2013.01);
Abstract

The present invention is directed to compounds of Formula I:

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