The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2015
Filed:
Oct. 23, 2012
Applicant:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Erich Koller, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); C12N 15/11 (2006.01); C12Q 1/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); C12Q 1/025 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3517 (2013.01); C12N 2320/10 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.