The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2015
Filed:
Feb. 28, 2013
Applicant:
Bioarctic Neuroscience Ab, Stockholm, SE;
Inventors:
Pär Gellerfors, Lidingö, SE;
Lars Lannfelt, Stockholm, SE;
Assignee:
BioArctic Neuroscience AB, Stockholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A01N 37/18 (2006.01); A01N 61/00 (2006.01); C07K 16/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); G01N 2800/2821 (2013.01); C07K 14/4711 (2013.01); G01N 2800/387 (2013.01);
Abstract
The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.