The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2015
Filed:
Jul. 01, 2013
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Jeonghoon Sun, Thousan Oaks, CA (US);
Lei-Ting Tony Tam, Thousand Oaks, CA (US);
Huiquan Han, Thousand Oaks, CA (US);
Keith Soo-Nyung Kwak, Thousand Oaks, CA (US);
Xiaolan Zhou, Thousand Oaks, CA (US);
John Lu, Culver City, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); A61K 38/45 (2006.01); A61K 31/513 (2006.01); A61K 31/655 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 38/50 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); C07K 14/71 (2013.01); A61K 38/45 (2013.01); A61K 31/513 (2013.01); A61K 31/655 (2013.01); A61K 38/177 (2013.01); A61K 38/179 (2013.01); A61K 38/193 (2013.01); A61K 38/2013 (2013.01); A61K 38/212 (2013.01); A61K 38/50 (2013.01); C12Y 305/01001 (2013.01);
Abstract
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.