The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2015
Filed:
Feb. 21, 2008
Heather R. Sanders, Winchester, CA (US);
Kevin Z. Qu, Irvine, CA (US);
Charles M. Strom, San Clemente, CA (US);
Richard A. Bender, Dana Point, CA (US);
Heather R. Sanders, Winchester, CA (US);
Kevin Z. Qu, Irvine, CA (US);
Charles M. Strom, San Clemente, CA (US);
Richard A. Bender, Dana Point, CA (US);
Quest Diagnostics Investments Incorporated, Wilmington, DE (US);
Abstract
Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.