The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Aug. 14, 2008
Applicants:
Carol Anne Colton, Cary, NC (US);
Michael Peter Vitek, Cary, NC (US);
Judianne Davis, East Setauket, NY (US);
William E. Vannostrand, East Setauket, NY (US);
Inventors:
Carol Anne Colton, Cary, NC (US);
Michael Peter Vitek, Cary, NC (US);
Judianne Davis, East Setauket, NY (US);
William E. VanNostrand, East Setauket, NY (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); G01N 33/00 (2006.01); A01K 67/027 (2006.01); A61K 49/00 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); A01K 2217/054 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0312 (2013.01); A61K 49/0008 (2013.01); C12N 15/8509 (2013.01);
Abstract
A modified non-human warm-blooded vertebrate animal in which a biologically active human APP polypeptide is expressed, and in which function of its inducible Nitric Oxide Synthase (iNOS) protein is reduced as compared to a non-modified animal, methods of making the animal, and methods of testing a candidate composition for activity in the treatment of Alzheimer's Disease using the animal.