The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Dec. 10, 2012
Nanjing University of Technology, Nanjing, CN;
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Donglu, CN;
Chunlei LV, Huancheng Donglu, CN;
Shiqing Pi, Huancheng Donglu, CN;
Jianhui Chen, Huancheng Donglu, CN;
Dingqiang Lu, Huancheng Donglu, CN;
Pingkai Ouyang, Huancheng Donglu, CN;
Nanjing University of Technology, Nanjing, CN;
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Huancheng Donglu, CN;
Abstract
Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.