The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Mar. 25, 2014
David Hook, Rheinfelden, CH;
Thomas Ruch, Frenkendorf, CH;
Bernard Riss, Huningue, FR;
Bernhard Wietfeld, Efringen-Kirchen, DE;
Gottfried Sedelmeier, Schallstadt, DE;
Matthias Napp, Lörrach, CH;
Markus Bänziger, Bubendorf, CH;
Steven Hawker, Hertfordshire, GB;
Lech Ciszewski, Morristown, NJ (US);
Liladhar Murlidhar Waykole, Succasunna, NJ (US);
David Hook, Rheinfelden, CH;
Thomas Ruch, Frenkendorf, CH;
Bernard Riss, Huningue, FR;
Bernhard Wietfeld, Efringen-Kirchen, DE;
Gottfried Sedelmeier, Schallstadt, DE;
Matthias Napp, Lörrach, CH;
Markus Bänziger, Bubendorf, CH;
Steven Hawker, Hertfordshire, GB;
Lech Ciszewski, Morristown, NJ (US);
Liladhar Murlidhar Waykole, Succasunna, NJ (US);
Novartis AG, Basel, CH;
Abstract
The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.