The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2015

Filed:

May. 10, 2012
Applicants:

John A. Beutler, Union Bridge, MD (US);

Stuart F. J. Legrice, Poolesville, MD (US);

Craig Thomas, Gaithersburg, MD (US);

Jian-kang Jiang, Columbia, MD (US);

Suhman Chung, Frederick, MD (US);

Jennifer Wilson, Frederick, MD (US);

Inventors:

John A. Beutler, Union Bridge, MD (US);

Stuart F. J. LeGrice, Poolesville, MD (US);

Craig Thomas, Gaithersburg, MD (US);

Jian-Kang Jiang, Columbia, MD (US);

Suhman Chung, Frederick, MD (US);

Jennifer Wilson, Frederick, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/12 (2006.01); C07D 233/60 (2006.01); C07C 49/733 (2006.01); C07C 225/18 (2006.01); C07C 317/24 (2006.01); C07C 323/22 (2006.01); A61K 31/4453 (2006.01); C07C 225/14 (2006.01); C07D 295/088 (2006.01); A61K 31/122 (2006.01); A61K 31/4164 (2006.01); A61K 45/06 (2006.01); C07C 49/573 (2006.01); C07D 233/64 (2006.01); C07D 295/116 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4453 (2013.01); C07C 49/733 (2013.01); C07C 225/14 (2013.01); C07C 317/24 (2013.01); C07C 323/22 (2013.01); C07D 233/60 (2013.01); C07D 295/088 (2013.01); A61K 31/122 (2013.01); A61K 31/4164 (2013.01); A61K 45/06 (2013.01); C07C 49/573 (2013.01); C07D 233/64 (2013.01); C07D 295/116 (2013.01); C07C 2102/32 (2013.01);
Abstract

Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R, R, and Rare as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).


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