The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Dec. 18, 2006
Anthony Mannino, Maryland Heights, MO (US);
Erik R. Hoefgin, Springfield, IL (US);
Lloyd P. Hill, St. Louis, MO (US);
Henry J. Buehler, St. Louis, MO (US);
Anthony Mannino, Maryland Heights, MO (US);
Erik R. Hoefgin, Springfield, IL (US);
Lloyd P. Hill, St. Louis, MO (US);
Henry J. Buehler, St. Louis, MO (US);
Mallinckrodt LLC, Hazelwood, MO (US);
Abstract
There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.