The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2015

Filed:

Nov. 30, 2012
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Sean P. Ahearn, Somerville, MA (US);

Matthew Christopher, Brookline, MA (US);

Christopher Dinsmore, Newton, MA (US);

Joon Jung, Natick, MA (US);

Qinglin Pu, Melrose, MA (US);

Alexey Rivkin, San Francisco, CA (US);

Mark E. Scott, Andover, MA (US);

David J. Witter, Norfolk, MA (US);

Hyun Chong Woo, Natick, MA (US);

Brandon Cash, Framingham, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 417/04 (2006.01); C07D 413/04 (2006.01); A61K 31/519 (2006.01); A61P 19/02 (2006.01); C07D 519/00 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07D 471/04 (2013.01);
Abstract

The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I.


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