The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Aug. 25, 2011
Applicant:
Gene Shen, Santa Clara, CA (US);
Inventor:
Gene Shen, Santa Clara, CA (US);
Assignee:
Pacific Biosciences, Inc., Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 17/00 (2006.01); A61K 38/14 (2006.01); C12Q 1/68 (2006.01); C07D 209/14 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C09B 23/01 (2006.01); C09B 23/06 (2006.01); C09B 23/08 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C07D 209/14 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C09B 23/0025 (2013.01); C09B 23/0033 (2013.01); C09B 23/0066 (2013.01); C09B 23/06 (2013.01); C09B 23/083 (2013.01); G01N 33/582 (2013.01);
Abstract
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.