The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2015

Filed:

May. 09, 2012
Applicants:

Byung Heon Lee, Daegu, KR;

IN San Kim, Daegu, KR;

Inventors:

Byung Heon Lee, Daegu, KR;

In San Kim, Daegu, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/06 (2006.01); A61K 38/08 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48246 (2013.01); A61K 49/0032 (2013.01); A61K 49/0043 (2013.01); A61K 49/0056 (2013.01); C07K 7/06 (2013.01); A61K 38/00 (2013.01); C07K 2319/33 (2013.01); G01N 2510/00 (2013.01);
Abstract

Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X-Val-Ala-Pro-X(I), wherein Xis an amino acid with polar uncharged side chain and Xis an amino acid with positive charged side chain. The isolated polypeptide of the present invention may be useful for detecting apoptotic cells, as well as detecting and imaging apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue, and arteriosclerosis site; the polypeptide is useful for targeted drug delivery thereto.


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