The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2015

Filed:

Oct. 08, 2013
Applicant:

Icos Corporation, Indianapolis, IN (US);

Inventors:

Kerry W. Fowler, Seattle, WA (US);

Danwen Huang, Bellevue, WA (US);

Edward A. Kesicki, Bothell, WA (US);

Hua Chee Ooi, Mill Creek, WA (US);

Amy Oliver, Bothell, WA (US);

Fuqiang Ruan, Bellevue, WA (US);

Jennifer Treiberg, Redmond, WA (US);

Kamal Deep Puri, Lynnwood, WA (US);

Assignee:

ICOS Corporation, Foster City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); C07D 239/91 (2006.01); A61K 31/52 (2006.01); C07D 473/16 (2006.01); C07D 473/34 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/52 (2013.01); C07D 473/16 (2013.01); C07D 473/34 (2013.01); C07D 487/04 (2013.01);
Abstract

Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. Exemplary compounds disclosed in this application are shown below:


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