The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Mar. 21, 2013
Applicant:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Eric E. Swayze, Encinitas, CA (US);
Andrew M. Siwkowski, Carlsbad, CA (US);
Punit P. Seth, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 19/10 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); A61K 31/712 (2013.01); A61K 31/7125 (2013.01); C07H 21/04 (2013.01);
Abstract
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.