The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
May. 12, 2014
Bristol-myers Squibb Company, Princeton, NJ (US);
Sharon Cload, Cambridge, MA (US);
Linda Engle, Framingham, MA (US);
Dasa Lipovsek, Cambridge, MA (US);
Malavi Madireddi, West Windsor, NJ (US);
Ginger Chao Rakestraw, Cambridge, MA (US);
Joanna Swain, Concord, MA (US);
Wenjun Zhao, Montgomery, NJ (US);
Martin J. Corbett, Mount Holly, NJ (US);
Alexander T. Kozhich, Princeton, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.