The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Mar. 15, 2013
Applicant:
Merck Patent Gesellschaft Mit Beschrankter Haftung, Darmstadt, DE;
Inventors:
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/30 (2006.01); G01N 33/53 (2006.01); C12N 5/00 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C07H 21/04 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); G01N 33/566 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2839 (2013.01); C07K 16/00 (2013.01); G01N 33/566 (2013.01); G01N 2333/70546 (2013.01);
Abstract
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.