The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Aug. 20, 2008
Ping I. Lee, Toronto, CA;
Yan LI, Hangzhou, CN;
Ping I. Lee, Toronto, CA;
Yan Li, Hangzhou, CN;
University of Toronto, , CA;
Abstract
A bio-adhesive supramacromolecular complex of the general formula: wherein Ris independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; Ris independently selected from the group consisting of C1-6 alkyl; Rand Rare independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; Ris independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T, T, Tand Tare independently selected polymer residues; and m, m, m, nand nare integers selected from at least 25; and wherein P has a molecular weight of about 1×10to 1×10and Q has a molecular weight of about 1×10to 1×10. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described.