The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Oct. 20, 2012
Seattle Genetics, Inc., Bothell, WA (US);
Hans-Georg Lerchen, Leverkusen, DE;
Lars Linden, Düsseldorf, DE;
Sherif El Sheikh, Essen, DE;
Jörg Willuda, Glienicke/Nordbahn, DE;
Charlotte Christine Kopitz, Berlin, DE;
Joachim Schuhmacher, Wuppertal, DE;
Simone Greven, Dormagen, DE;
Christoph Mahlert, Wuppertal, DE;
Beatrix Stelte-Ludwig, Wülfrath, DE;
Sven Golfier, Berlin, DE;
Rudolf Beier, Berlin, DE;
Iring Heisler, Wuppertal, DE;
Axel Harrenga, Wuppertal, DE;
Karl-Heinz Thierauch, Berlin, DE;
Sandra Bruder, Leverkusen, DE;
Heike Petrul, Berlin, DE;
Hannah Jöriβen, Essen, DE;
Sandra Borkowski, Hohen Neuendorf, DE;
Seattle Genetics, Inc., Bothell, WA (US);
Abstract
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practiced as a monotherapy or else in combination with other medicaments or further therapeutic measures.