The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Apr. 09, 2007
Jie Wu, Tampa, FL (US);
Nicholas J. Lawrence, Tampa, FL (US);
Said M. Sebti, Tampa, FL (US);
Harshani R. Lawrence, Tampa, FL (US);
Jie Wu, Tampa, FL (US);
Nicholas J. Lawrence, Tampa, FL (US);
Said M. Sebti, Tampa, FL (US);
Harshani R. Lawrence, Tampa, FL (US);
University of South Florida, Tampa, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Abstract
Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and NSC-117199 have been identified as Shp2 PTP inhibitors. Significantly, NSC-87877 is active in cell-based assays and has no detectable off-target effects in the EGF-stimulated Erk 1/2 activation pathway. Additionally, a number of analogs of NSC-117199 have been produced. These analogs exhibit enhanced protein tyrosine phosphatase inhibition and are found to be potent and/or selective inhibitors of Shp1 and/or Shp2 protein tyrosine phosphatases.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile