The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2015

Filed:

Aug. 15, 2012
Applicants:

Hariprasad Vankayalapati, Draper, UT (US);

Venkataswamy Sorna, Salt Lake City, UT (US);

Steven L. Warner, Sandy, UT (US);

Bret Stephens, Riverton, UT (US);

David J. Bearss, Alpine, UT (US);

Sunil Sharma, Salt Lake City, UT (US);

Inventors:

Hariprasad Vankayalapati, Draper, UT (US);

Venkataswamy Sorna, Salt Lake City, UT (US);

Steven L. Warner, Sandy, UT (US);

Bret Stephens, Riverton, UT (US);

David J. Bearss, Alpine, UT (US);

Sunil Sharma, Salt Lake City, UT (US);

Assignee:

University of Utah Research Foundation, Salt Lake City, UT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 33/26 (2006.01); A01N 31/08 (2006.01); A61K 31/05 (2006.01); C07C 241/00 (2006.01); C07C 243/00 (2006.01); C07D 295/26 (2006.01); C07C 311/16 (2006.01); C07C 311/46 (2006.01); C07D 205/04 (2006.01); C07D 295/155 (2006.01);
U.S. Cl.
CPC ...
C07D 295/26 (2013.01); C07C 311/16 (2013.01); C07C 311/46 (2013.01); C07D 205/04 (2013.01); C07D 295/155 (2013.01);
Abstract

In one aspect, the invention relates to substituted (E)-N'-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.


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