The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Jun. 27, 2013
Applicant:
University of Virginia Patent Foundation, Charlottesville, VA (US);
Inventors:
Timothy L. MacDonald, Charlottesville, VA (US);
Jerry L. Nadler, Charlottesville, VA (US);
Peng Cui, Charlottesville, VA (US);
Assignee:
University of Virginia Patent Foundation, Charlottesville, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/405 (2006.01); C07D 209/08 (2006.01); A61K 31/538 (2006.01); C07C 215/68 (2006.01); C07C 219/32 (2006.01); C07D 209/80 (2006.01); C07D 221/08 (2006.01); C07D 223/22 (2006.01); C07D 241/08 (2006.01); C07D 241/18 (2006.01); C07D 249/12 (2006.01); C07D 253/04 (2006.01); C07D 265/26 (2006.01); C07D 265/36 (2006.01); C07D 265/38 (2006.01); C07D 275/04 (2006.01); C07D 279/22 (2006.01); C07D 487/04 (2006.01); A61K 31/404 (2006.01); A61K 31/4196 (2006.01); A61K 31/495 (2006.01); A61K 31/502 (2006.01); A61K 31/53 (2006.01);
U.S. Cl.
CPC ...
A61K 31/538 (2013.01); C07C 215/68 (2013.01); C07C 219/32 (2013.01); C07D 209/08 (2013.01); C07D 209/80 (2013.01); C07D 221/08 (2013.01); C07D 223/22 (2013.01); C07D 241/08 (2013.01); C07D 241/18 (2013.01); C07D 249/12 (2013.01); C07D 253/04 (2013.01); C07D 265/26 (2013.01); C07D 265/36 (2013.01); C07D 265/38 (2013.01); C07D 275/04 (2013.01); C07D 279/22 (2013.01); C07D 487/04 (2013.01); A61K 31/404 (2013.01); A61K 31/405 (2013.01); A61K 31/4196 (2013.01); A61K 31/495 (2013.01); A61K 31/502 (2013.01); A61K 31/53 (2013.01);
Abstract
The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.