The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2015

Filed:

Jul. 02, 2010
Applicants:

Wang Shen, San Mateo, CA (US);

Aimin Zhang, Castro Valley, CA (US);

Junfa Fan, Hayward, CA (US);

Xiaoling Zheng, Fremont, CA (US);

Inventors:

Wang Shen, San Mateo, CA (US);

Aimin Zhang, Castro Valley, CA (US);

Junfa Fan, Hayward, CA (US);

Xiaoling Zheng, Fremont, CA (US);

Assignee:

Newgen Therapeutics, Inc., Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/54 (2006.01); A61K 31/517 (2006.01); C07D 239/72 (2006.01); C07D 401/00 (2006.01); C07F 9/6512 (2006.01); C07F 9/6558 (2006.01); C07F 9/6568 (2006.01); C07F 9/6571 (2006.01);
U.S. Cl.
CPC ...
C07F 9/65685 (2013.01); C07F 9/65128 (2013.01); C07F 9/65586 (2013.01); C07F 9/657181 (2013.01);
Abstract

Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.


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