The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Nov. 16, 2007
Applicants:
Johannes Petrus Thomas Maria Van Leeuwen, Amstelveen, NL;
Hermanus Johannes Marco Eijken, Rotterdam, NL;
Inventors:
Johannes Petrus Thomas Maria Van Leeuwen, Amstelveen, NL;
Hermanus Johannes Marco Eijken, Rotterdam, NL;
Assignee:
Arcarios B.V., Rotterdam, NL;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 19/08 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C12N 5/077 (2010.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0654 (2013.01); A61K 38/17 (2013.01); C12N 2501/16 (2013.01);
Abstract
The present invention relates to methods for selecting a candidate therapeutic agent for controlling mineralization of an extracellular matrix in a tissue of a subject. The invention further relates to a cell culture mineralization model comprising a culture of an extracellular matrix producing cell under conditions that support extracellular matrix formation and matrix maturation, a test compound, and means and methods for determining in expression levels of genes encoding matrix proteins.