The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2015

Filed:

Aug. 02, 2006
Applicants:

Douglas T. Yamanishi, Carlsbad, CA (US);

Paul G. Hujsak, San Diego, CA (US);

Sara F. Snyder, San Francisco, CA (US);

George Walker, San Diego, CA (US);

Junquan Xu, San Diego, CA (US);

Mingxian Huang, San Diego, CA (US);

Guoliang Tao, San Diego, CA (US);

Lei Wu, San Diego, CA (US);

Xiaobo Wang, San Diego, CA (US);

Joe Ouyang, San Diego, CA (US);

Charina Schmitigal, San Diego, CA (US);

Jing Cheng, San Diego, CA (US);

Jia Xu, San Diego, CA (US);

Inventors:

Douglas T. Yamanishi, Carlsbad, CA (US);

Paul G. Hujsak, San Diego, CA (US);

Sara F. Snyder, San Francisco, CA (US);

George Walker, San Diego, CA (US);

Junquan Xu, San Diego, CA (US);

Mingxian Huang, San Diego, CA (US);

Guoliang Tao, San Diego, CA (US);

Lei Wu, San Diego, CA (US);

Xiaobo Wang, San Diego, CA (US);

Joe Ouyang, San Diego, CA (US);

Charina Schmitigal, San Diego, CA (US);

Jing Cheng, San Diego, CA (US);

Jia Xu, San Diego, CA (US);

Assignee:

Aviva Biosciences Corporation, San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/24 (2006.01); C12Q 1/68 (2006.01); G01N 1/40 (2006.01); G01N 33/569 (2006.01); G01N 33/574 (2006.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6881 (2013.01); G01N 1/40 (2013.01); G01N 1/4077 (2013.01); G01N 33/56966 (2013.01); G01N 33/57407 (2013.01); B01L 3/5027 (2013.01); G01N 2333/4724 (2013.01);
Abstract

The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.


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