The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Feb. 07, 2006
Volker Albrecht, Jena, DE;
Alfred Fahr, Cöbe/Marburg, DE;
Dietrich Scheglmann, Jena-Cospeda, DE;
Susanna Gräfe, Jena, DE;
Wolfgang Neuberger, F.T. Labuan, MY;
Volker Albrecht, Jena, DE;
Alfred Fahr, Cöbe/Marburg, DE;
Dietrich Scheglmann, Jena-Cospeda, DE;
Susanna Gräfe, Jena, DE;
Wolfgang Neuberger, F.T. Labuan, MY;
Biolitec Pharma Marketing Ltd, F.T. Labuan, MY;
Abstract
Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. At least one of the phospholipids in the liposomes has been linked with poly ethylene glycol (PEG) as an integral part of the phospholipids. The formed pegylated liposomes contain the hydrophobic photosensitizer within the lipid bilayer membrane. Pegylation of liposomes carrying the hydrophobic photosensitizer helps to maintain the drug level within the therapeutic window for longer time periods and provides the drug a longer circulating half life in vivo. Further the pegylated formulation of hydrophobic photosensitizers shows improved pharmacokinetics over standard non-liposomal formulations thus enhancing the efficacy of PDT with the pegylated liposomal formulations.