The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Sep. 21, 2012
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite DE Strasbourg, Strasbourg, FR;
Martial Ruat, Orsay, FR;
Hélène Faure, Gif-sur-Yvette, FR;
Hermine Roudaut, Marly-la-Ville, FR;
Lucile Hoch, Auffargis, FR;
Angèle Schoenfelder, Lampertheim, FR;
Maurizio Taddei, Monteriggioni, IT;
André Mann, Ostwald, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Universite de Strasbourg, Strasbourg, FR;
Abstract
The invention relates to compounds of formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, treatment of neurodegenerative diseases, treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring treatment of cerebrovascular accidents and cardiovascular accidents, treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The invention also relates to pharmaceutical compositions having a compound of formula (I). The invention also relates to a method for radio-marking compounds having formula (I), the marked compounds, and the use of the compounds as research tools, and method for screening and/or identifying ligands in the Smoothened receptor (Smo) binding sites, methods for identifying agonists and antagonists of the Smoothened receptor, and a method for identifying cells.