The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Jul. 05, 2011
Applicants:
Umberto Ciambecchini, Patricia, IT;
Stefano Turchetta, Patricia, IT;
Maurizio Zenoni, Patricia, IT;
Lorenzo DE Ferra, Patricia, IT;
Paolo Brandi, Patricia, IT;
Inventors:
Umberto Ciambecchini, Patricia, IT;
Stefano Turchetta, Patricia, IT;
Maurizio Zenoni, Patricia, IT;
Lorenzo De Ferra, Patricia, IT;
Paolo Brandi, Patricia, IT;
Assignee:
Chemi S.p.A., Cinisello Balsamo, IT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01);
Abstract
The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: